Purinergic Receptors Crosstalk with CCR5 to Amplify Ca2+ Signaling
نویسندگان
چکیده
منابع مشابه
Signaling at purinergic P2X receptors.
P2X receptors are membrane cation channels gated by extracellular ATP. Seven P2X receptor subunits (P2X(1-7)) are widely distributed in excitable and nonexcitable cells of vertebrates. They play key roles in inter alia afferent signaling (including pain), regulation of renal blood flow, vascular endothelium, and inflammatory responses. We summarize the evidence for these and other roles, emphas...
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Extracellular ATP and ADP have been shown to exhibit potent angiogenic effects on pulmonary artery adventitial vasa vasorum endothelial cells (VVEC). However, the molecular signaling mechanisms of extracellular nucleotide-mediated angiogenesis remain not fully elucidated. Since elevation of intracellular Ca(2+) concentration ([Ca(2+)](i)) is required for cell proliferation and occurs in respons...
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ژورنال
عنوان ژورنال: Cellular and Molecular Neurobiology
سال: 2020
ISSN: 0272-4340,1573-6830
DOI: 10.1007/s10571-020-01002-1